To elucidate the clinical characteristics-especially its clinical pattern and outcome-of children with encephalopathy, we carried out a retrospective review on medical records of 45 patients who were initially diagnosed as encephalopathy except
mumps
meningitis, Reye's syndome and neonatal hypoxic ischemic encephalopathy at the Department of pediatrics, Hanyang University children's hospital from Jaunary 1986 to February 1994.
@ES The results were summarized as follows:
@EN 1) Twenty five were male and twenty were female with male to female ratio 1.3:l.
2) There were no association with death rate and conscious level, abnormal liver function test, and sugar level in CSF on admission.
3) Death rate (33.3%) of group with seizure was higher than that (13.3%) of group without seizure on admission, but there was no statistical significance (p=0.28).
4) Death rate (7.5%) of group (Ⅰ) which initial therapy started before 12hours was lower than that (43.4%) of group (Ⅱ) which initial therapy started after 12hours, but there was no statistical significance (p=0.09). However complete recovery
rate
(66.7%) of the former group was higher than that (26.7%) of the latter group with statistical significance (p<0.05).
Therefore, early diagnosis and treatment before 12hours was essential to recovery and good prognosis in childern with acute encephalopathy.
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